Comic Life by Plasq is one of my favorite applications! Comic Life is available for both Mac and PC. Comic Life is a very simple desktop publishing software that can be used for making comics, storyboards, diagrams, newsletters and lots more. Students love using Comic Life especially when they can add their own picture using Photo Booth.
If you need some ideas for using Comic Life in the classroom, visit Comic Life Meets the Curriculum. You'll find many student samples and templates to download. Great site!
We've added a few more resources for using Comic Life on our Buhler Tech Wiki.